资源类型

期刊论文 168

会议视频 6

会议信息 4

年份

2023 11

2022 15

2021 9

2020 15

2019 14

2018 8

2017 9

2016 9

2015 9

2014 8

2013 5

2012 4

2011 14

2010 8

2008 9

2007 7

2006 8

2005 1

2004 3

2003 1

展开 ︾

关键词

实时监控 4

仿真 3

实时控制 3

实物期权 3

天基信息 2

实时服务 2

实时检测 2

实时荧光定量PCR 2

工程管理 2

施工进度 2

网络空间 2

2 Mb/s高速信令 1

ATP荧光检测 1

BNCT 1

Biological Rhythms 1

Chronobiology 1

DNA 1

NASICON 1

SAA7121 1

展开 ︾

检索范围：

排序： 展示方式：

General modeling and optimization technique for real-world earth observation satellite scheduling

《工程管理前沿（英文）》   页码 695-709 doi: 10.1007/s42524-023-0263-3

摘要： Over the last two decades, many modeling and optimization techniques have been developed for earth observation satellite (EOS) scheduling problems, but few of them show good generality to be engineered in real-world applications. This study proposes a general modeling and optimization technique for common and real-world EOS scheduling cases; it includes a decoupled framework, a general modeling method, and an easy-to-use algorithm library. In this technique, a framework that decouples the modeling, constraints, and optimization of EOS scheduling problems is built. With this framework, the EOS scheduling problems are appropriately modeled in a general manner, where the executable opportunity, another format of the well-known visible time window per EOS operation, is viewed as a selectable resource to be optimized. On this basis, 10 types of optimization algorithms, such as Tabu search and genetic algorithm, and a parallel competitive memetic algorithm, are developed. For simplified EOS scheduling problems, the proposed technique shows better performance in applicability and effectiveness than the state-of-the-art algorithms. In addition, a complicatedly constrained real-world benchmark exampled by a four-EOS Chinese commercial constellation is provided, and the technique is qualified and outperforms the in-use scheduling system by more than 50%.

关键词： earth observation satellite     scheduling     general technique     optimization algorithm     commercial constellation     real-world     benchmark    

HTML PDF 收藏

Scientific computation of big data in real-world clinical research

null

《医学前沿（英文）》 2014年 第8卷 第3期   页码 310-315 doi: 10.1007/s11684-014-0358-7

摘要：

The advent of the big data era creates both opportunities and challenges for traditional Chinese medicine (TCM). This study describes the origin, concept, connotation, and value of studies regarding the scientific computation of TCM. It also discusses the integration of science, technology, and medicine under the guidance of the paradigm of real-world, clinical scientific research. TCM clinical diagnosis, treatment, and knowledge were traditionally limited to literature and sensation levels; however, primary methods are used to convert them into statistics, such as the methods of feature subset optimizing, multi-label learning, and complex networks based on complexity, intelligence, data, and computing sciences. Furthermore, these methods are applied in the modeling and analysis of the various complex relationships in individualized clinical diagnosis and treatment, as well as in decision-making related to such diagnosis and treatment. Thus, these methods strongly support the real-world clinical research paradigm of TCM.

关键词： big data     real world     clinical research     Chinese medicine     medical computing    

HTML PDF 收藏

Discussion of solutions to ethical issues in real-world study

null

《医学前沿（英文）》 2014年 第8卷 第3期   页码 316-320 doi: 10.1007/s11684-014-0354-y

摘要：

In recent years, the paradigm of real-world study (RWS) has been at the forefront of clinical research worldwide, particularly in the field of traditional Chinese medicine. In this paper, basic features and nature of real-world clinical studies are discussed, and ethical issues in different stages of RWS are raised and reviewed. Moreover, some preliminary solutions to these issues, such as protecting subjects during the process of RWS and performing ethical review, are presented based on recent practices and basic ethical rules to improve the scientific validity and ethical level of RWS.

关键词： real-world study     ethics     strategy    

HTML PDF 收藏

Clinical data quality problems and countermeasure for real world study

null

《医学前沿（英文）》 2014年 第8卷 第3期   页码 352-357 doi: 10.1007/s11684-014-0351-1

摘要：

Real world study (RWS) has become a hotspot for clinical research. Data quality plays a vital role in research achievement and other clinical research fields. In this paper, the common quality problems in the RWS of traditional Chinese medicine are discussed, and a countermeasure is proposed.

关键词： real world study     traditional Chinese medicine     clinical and research information sharing system     data quality problem     data quality control    

HTML PDF 收藏

Quantification of emission variability for off-road equipment in China based on real-world measurements

《环境科学与工程前沿（英文）》 2022年 第16卷 第2期 doi: 10.1007/s11783-021-1455-x

摘要：

• Emissions from 53 in-use diesel-fueled off-road equipment were measured.

关键词： Off-road equipment     Portable emission measurement system (PEMS)     Real-world emissions     Diesel engine    

HTML PDF 收藏

Construction of a shared system-based real-world clinical research system

null

《医学前沿（英文）》 2014年 第8卷 第3期   页码 382-388 doi: 10.1007/s11684-014-0368-5

摘要：

Hubei Provincial Hospital of Traditional Chinese Medicine established research outpatient clinics to contribute to the major disease-entity research conducted by the National Traditional Chinese Medicine Clinical Research Base and to the construction of the National Traditional Chinese Medicine Treatment and Clinical Research Information Sharing System. With a view of developing a “real-world traditional Chinese medicine clinical research paradigm,” these clinics explored the mode of constructing research outpatient clinics from the aspects of clinical research, health management, and characteristics diagnosis and treatment.

关键词： clinical research     shared system     real world     research outpatient clinic     research hospital    

HTML PDF 收藏

Experience inheritance from famous specialists based on real-world clinical research paradigm of traditional

null

《医学前沿（英文）》 2014年 第8卷 第3期   页码 300-309 doi: 10.1007/s11684-014-0357-8

摘要：

The current modes of experience inheritance from famous specialists in traditional Chinese medicine (TCM) include master and disciple, literature review, clinical-epidemiology-based clinical research observation, and analysis and data mining via computer and database technologies. Each mode has its advantages and disadvantages. However, a scientific and instructive experience inheritance mode has not been developed. The advent of the big data era as well as the formation and practice accumulation of the TCM clinical research paradigm in the real world have provided new perspectives, techniques, and methods for inheriting experience from famous TCM specialists. Through continuous exploration and practice, the research group proposes the innovation research mode based on the real-world TCM clinical research paradigm, which involves the inheritance and innovation of the existing modes. This mode is formulated in line with its own development regularity of TCM and is expected to become the main mode of experience inheritance in the clinical field.

关键词： traditional Chinese medicine (TCM)     real world     clinical research paradigm     famous specialist     experience inheritance    

HTML PDF 收藏

Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris

Yufeng Zhao, Xueyun Yu, Xinyu Cao, Lin Luo, Liyun He, Shusong Mao, Li Ma, Peijing Rong, Yuxue Zhao, Guozheng Li, Baoyan Liu

《医学前沿（英文）》 2018年 第12卷 第5期   页码 566-571 doi: 10.1007/s11684-017-0556-1

摘要：

Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance for clinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCM treatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM Clinical Research Information Sharing System for TCM clinics and research. Syndromes were automatically extracted with the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndrome classifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blood deficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation and blood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61% of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accounted for 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qi stagnation.

关键词： syndrome differentiation     real-world study     coronary heart disease with angina pectoris     cluster analysis    

HTML PDF 收藏

Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective cohort study

《医学前沿（英文）》   页码 867-877 doi: 10.1007/s11684-023-0995-9

摘要： Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of inactivated vaccines is not well characterized in people with comorbidities, who are at high risk of severe infection. We compared the risk of SARS-CoV-2 infection after complete vaccination with Sinopharm/BBIBP in people with comorbidities (e.g., autoimmune diseases, cardiovascular disease, chronic lung disease, and diabetes) with healthy individuals using a Cox-proportional hazard model. In July–September 2021, a total of 10 548 people (comorbidities, 2143; healthy, 8405) receiving the complete primary series of vaccination with Sinopharm/BBIBP in Bangkok, Thailand were prospectively followed for SARS-CoV-2 infection through text messaging and telephone interviewing for 6 months. A total of 295 infections from 284 participants were found. HRs (95% CI) of individuals with any comorbidities did not increase (unadjusted, 1.02 (0.77–1.36), P = 0.89; adjusted, 1.04 (0.78–1.38), P = 0.81). HRs significantly increased in the subgroup of autoimmune diseases (unadjusted, 2.64 (1.09–6.38), P = 0.032; adjusted, 4.45 (1.83–10.83), P = 0.001) but not in cardiovascular disease, chronic lung disease, or diabetes. The protection against SARS-CoV-2 infection of the Sinopharm vaccine was similar in participants with any comorbidities vs. healthy individuals. However, the protection appeared lower in the subgroup of autoimmune diseases, which may reflect suboptimal immune responses among these people.

关键词： COVID-19     Sinopharm/BBIBP vaccine     immunocompromised patients     real-world    

HTML PDF 收藏

” treatment plan for reducing mortality of patients with hepatitis B-related liver failure based on real-world

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

《医学前沿（英文）》 2021年 第15卷 第3期   页码 495-505 doi: 10.1007/s11684-020-0790-9

摘要： On the basis of real-world clinical data, the study aimed to explore the effect and mechanisms of the treatment plan of “traditional Chinese medicine (TCM) regulating liver regeneration.” A total of 457 patients with HBV-related liver failure were retrospectively collected. The patients were divided into three groups: the modern medicine control group (MMC group), patients treated with routine medical treatment; the control group combining traditional Chinese and Western medicine (CTW), patients treated with routine medical treatment plus the common TCM formula; and the treatment group of “TCM regulating liver regeneration” (RLR), patients treated with both routine medical treatment and the special TCM formula of RLR. After 8 weeks of treatment, the mortality of patients in the RLR group (12.31%) was significantly lower than those in the MMC (50%) and CTW (29.11%) groups. Total bilirubin level significantly decreased and albumin increased in the RLR group when compared with the MMC and CTW groups ( <0.05). In addition, there were significant differences in the expression of several cytokines related to liver regeneration in the RLR group compared with the MMC group. RLR treatment can decrease jaundice, improve liver function, and significantly reduce the mortality in patients with HBV-related liver failure. The mechanism may be related to the role of RLR treatment in influencing cytokines related to liver regeneration.

关键词： hepatitis B virus-related liver failure     traditional Chinese medicine     liver regeneration     liver regeneration microenvironment     cytokines    

HTML PDF 收藏

Real-world fuel consumption of light-duty passenger vehicles using on-board diagnostic (OBD) systems

Xuan Zheng, Sheng Lu, Liuhanzi Yang, Min Yan, Guangyi Xu, Xiaomeng Wu, Lixin Fu, Ye Wu

《环境科学与工程前沿（英文）》 2020年 第14卷 第2期 doi: 10.1007/s11783-019-1212-6

摘要： • Fuel consumption (FC) from LDPVs is measured using on-board diagnostic method (OBD). • The FC of the OBD is 7.1% lower than that of the carbon balance results. • The discrepancy between the approved FC and real-world FC is 13%±18%. • There is a strong relationship (R2=0.984) between the average speed and relative FC. An increasing discrepancy between real-world and type-approval fuel consumption for light-duty passenger vehicles (LDPVs) has been reported by several studies. Normally, real-world fuel consumption is measured primarily by a portable emission measurement system. The on-board diagnostic (OBD) approach, which is flexible and offers high-resolution data collection, is a promising fuel consumption monitoring method. Three LDPVs were tested with a laboratory dynamometer based on a type-approval cycle, the New European Driving Cycle (NEDC). Fuel consumption was measured by the OBD and constant-volume sampling system (CVS, a regulatory method) to verify the accuracy of the OBD values. The results of the OBD method and the regulatory carbon balance method exhibited a strong linear correlation (e.g., R2 = 0.906-0.977). Compared with the carbon balance results, the fuel consumption results using the OBD were 7.1%±4.3% lower on average. Furthermore, the real-world fuel consumption of six LDPVs was tested in Beijing using the OBD. The results showed that the normalized NEDC real-world fuel consumption of the tested vehicles was 13%±17% higher than the type-approval-based fuel consumption. Because the OBD values are lower than the actual fuel consumption, using a carbon balance method may result in a larger discrepancy between real-word and type-approval fuel consumption. By means of the operating mode binning and micro trip methods, a strong relationship (R2 = 0.984) was established between the average speed and relative fuel consumption. For congested roads (average vehicle speed less than 25 km/h), the fuel consumption of LDPVs is highly sensitive to changes in average speed.

关键词： Fuel consumption     Light-duty passenger vehicles     On-board diagnostic systems    

HTML PDF 收藏

Thinking and practice of accelerating transformation of traditional Chinese medicine from experience medicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

《医学前沿（英文）》 2011年 第5卷 第2期   页码 163-170 doi: 10.1007/s11684-011-0143-9

摘要： The gradual development of Chinese medicine is based on constant accumulation and summary of experience in clinical practice, but without the benefit of undergoing the experimental medicine stage. Although Chinese medicine has formed a systematic and unique theory system through thousands of years, with the development of evidence-based medicine, the bondage of the research methods of experience medicine to Chinese medicine is appearing. The rapid transition and transformation from experience medicine to evidence-based medicine have become important content in the development of Chinese medicine. According to the features of Chinese medicine, we propose the research idea of “taking two ways simultaneously,” which is the study both in the ideal condition and in the real world. Analyzing and constructing the theoretical basis and methodology of clinical research in the real world, and building the stage for research technique is key to the effective clinical research of Chinese medicine. Only by gradually maturing and completing the clinical research methods of the real world could we realize “taking two ways simultaneously” and complementing each other, continuously produce scientific and reliable evidence of Chinese medicine, as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine.

关键词： Chinese medicine     experience medicine     evidence-based medicine     real world    

HTML PDF 收藏

Collaborations of China with the world in Synbio

《化学科学与工程前沿（英文）》 2017年 第11卷 第1期   页码 1-2 doi: 10.1007/s11705-017-1638-y

HTML PDF 收藏

Scale study of sites and pavilions for World Expo 2010

ZHOU Zhuoyan, CHEN Yi

《结构与土木工程前沿（英文）》 2008年 第2卷 第1期   页码 102-106 doi: 10.1007/s11709-008-0012-z

摘要： The scale of sites and pavilions for World Expo 2010 (Shanghai World Expo) mainly refers to the study of their size including the area and number of exhibition hall needed in each pavilion and site with appropriate waiting area. All the design data of scale studied should reasonably meet the requirements during World Expo 2010 to accommodate large number of people for visiting and waiting to the full.

关键词： pavilion     study     number     appropriate     design    

HTML PDF 收藏

The Shanghai Corporate Pavilion design for World Expo in Shanghai 2010

Yung Ho CHANG

《结构与土木工程前沿（英文）》 2010年 第4卷 第4期   页码 519-521 doi: 10.1007/s11709-010-0093-3

摘要： New technologies are becoming today’s basic building blocks. This paper presents a case study of the Shanghai Corporate Pavilion for the 2010 World Expo in Shanghai. From the shape of the building to the use of solar energy, the Shanghai Corporate Pavilion incorporates the state-of-art technologies to convey the spirit of the architecture. It addresses the pressing issue of energy, environment, and sustainability and reflects the spirit of Shanghai as a historically progressive yet still fast moving international metropolis.

关键词： 2010 World Expo     LED lights     solar energy    

HTML PDF 收藏

标题 作者 时间 类型 操作

General modeling and optimization technique for real-world earth observation satellite scheduling

期刊论文

Scientific computation of big data in real-world clinical research

null

期刊论文

Discussion of solutions to ethical issues in real-world study

null

期刊论文

Clinical data quality problems and countermeasure for real world study

null

期刊论文

Quantification of emission variability for off-road equipment in China based on real-world measurements

期刊论文

Construction of a shared system-based real-world clinical research system

null

期刊论文

Experience inheritance from famous specialists based on real-world clinical research paradigm of traditional

null

期刊论文

Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris

Yufeng Zhao, Xueyun Yu, Xinyu Cao, Lin Luo, Liyun He, Shusong Mao, Li Ma, Peijing Rong, Yuxue Zhao, Guozheng Li, Baoyan Liu

期刊论文

Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective cohort study

期刊论文

” treatment plan for reducing mortality of patients with hepatitis B-related liver failure based on real-world

Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu

期刊论文

Real-world fuel consumption of light-duty passenger vehicles using on-board diagnostic (OBD) systems

Xuan Zheng, Sheng Lu, Liuhanzi Yang, Min Yan, Guangyi Xu, Xiaomeng Wu, Lixin Fu, Ye Wu

期刊论文

Thinking and practice of accelerating transformation of traditional Chinese medicine from experience medicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

期刊论文

Collaborations of China with the world in Synbio

期刊论文

Scale study of sites and pavilions for World Expo 2010

ZHOU Zhuoyan, CHEN Yi

期刊论文

The Shanghai Corporate Pavilion design for World Expo in Shanghai 2010

Yung Ho CHANG

期刊论文